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Dogs are one of the most loved animals on planet Earth. And there’s no surprise that the majority of households in America have dogs as pets. While these four-legged creatures give us plenty of happiness and joy, they can succumb to numerous illnesses and diseases.

This is why it becomes so important for pet parents to take care of their friendly buddies. And speaking of care, it is mandatory to protect your dogs from pesky parasites such as fleas and ticks.

There are many treatments available in the market; Simparica Trio and Trifexis are the best amongst them. But which one is better? Well, to find out, you need to read more.

Before we jump into the differences between Simparica Trio and Trifexis, it is important to know about the products. So here’s a brief description of the two.

Simparica Trio For Dogs

Simparica Trio is the advanced version of the well-renowned Simparica chews. It is a powerful and effective monthly chewy treatment that protects dogs and puppies from deadly heartworm disease. The chews also help in eliminating fleas and ticks including five tick types: Black-legged ‘deer’ ticks, American dog ticks, Gulf Coast ticks, Lone star ticks, and Brown dog ticks. Moreover, it is also effective against roundworms and hookworms. Besides, this treatment is safe for puppies over 8 weeks of age.

Trifexis For Dogs

Just like Simparica Trio, Trifexis is also a chewable treatment. It is helpful in eliminating fleas as well as prevents further infestations. The treatment also protects dogs against heartworm infection and helps in treating and controlling adult hookworms, roundworms, and whipworms. Moreover, this flavored treatment can be used on a monthly basis and is safe for all dog breeds and puppies over 8 weeks old.

[Learn] FAQ’s About Trifexis

Simparica Trio vs. Trifexis

Now that our readers have a fair amount of idea about both the products, it is time to compare them both. So, let’s have a look and see who is the winner!

Simparica Trio Or Trifexis

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Final Takeaway

From the above table, we can see that both products have their advantages and disadvantages. Thus, your selection will all boil down to your preference based on a few factors.

For instance, if your dog is suffering only from fleas, you can just opt for Trifexis. But if your buddy needs flea and tick protection, then Simparica Trio would be your obvious choice.

Similarly, if your dog needs whipworm elimination, go for Trifexis. Whereas if your buddy needs ticks, fleas, and roundworm protection, then Simparica Trio is the one.

Thus, your choice will be based on what your buddy needs the most. Hence, make the choice as per that.



Jesse McDaniel is an animal activist that raises concerns and spreads awareness regarding pet health issues. She is also a self-proclaimed pet lover who tends to support many pet shelters, assisting them with supplies and medical aid on a regular basis.