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Frontline Plus (COMBO) for Dogs

Frontline Plus (COMBO) for Large Dogs 45-88 lbs (Purple)

Pack Size Qty. Price Sale Price  
3 Pipette
$59.08 $35.45 By Product
6 Pipette
$113.22 $67.93 By Product
12 Pipette
$212.90 $127.74 By Product



Arguably, one of the most popular flea and tick control treatments for dogs, Frontline Combo stands high score as an easy to apply topical treatment for canines. A highly effective monthly treatment that is suitable for all breeds of dogs, Frontline Combo kills fleas, ticks and all flea life stages in one go. Being waterproof, it remains effective even after the pet gets wet and gives lasting protection for an entire month.

A Merial product, Frontline Combo is a spot-on treatment for killing fleas and ticks in 8 weeks and older puppies and dogs. It kills 100% fleas within 12 hours and ticks and chewing lice within 48 hours of application. Fipronil and S-methoprene are the active ingredients that attack the central nervous system of parasites, paralyze them and eventually kill them.

Frontline Combo provides month long protection to canines and saves them from flea and tick-borne diseases. Some of the diseases when kept untreated result in fatal conditions and prove deadly for the pet. It kills all flea life stages including egg, larvae and pupae, and thus eliminates chances of re-infestations.

Please be informed that as Merial is now part of Boehringer Ingelheim, the manufacturer’s name may vary on the product packs according to the stock availability.

Key Benefits
  • Topical flea control and prevention treatment for fleas and ticks.
  • Kills fleas, lone star ticks, American ticks, brown dog ticks and deer ticks.
  • Suitable for all breeds of 8 weeks and older puppies and dogs.
  • Waterproof treatment that remains effective after swimming and bathing the pet.
  • Protects the pet from flea and tick borne diseases.
  • Aids in treatment of Flea Allergy Dermatitis (FAD). 
Direction of use

As per the weight and size of dogs, Frontline Combo is made available in four different color-coded packs. Please refer dosage table for details.

Weigh your pet and choose the appropriate pack. Part the fur behind the neck of the pet. Make sure it is between the shoulder blades so that the pet cannot lick it.

Place the tip of the pipette on the spot and squeeze out all the content. Allow the application site to be dry. For small dogs and medium sized dogs, apply at just one spot while for larger dogs apply at 4-5 spots moving across the backbone to the base of the tail.

It is safe for breeding, pregnant and nursing female dogs while it is a must to take veterinarian guidance before treating sick, aged and debilitated dogs with Frontline Combo.


Color Code


Dog Size


0.67 ml

0-22 lbs


1.34 ml

23-44 lbs


2.68 ml

45-88 lbs


4.02 ml

89-132 lbs

  • Do not treat puppies under 8 weeks of age with Frontline Combo.
  • Do not use on cats or other animals.
  • Let the application site be completely dry. Do not allow the pet to lick the application site.
  • Do not allow children and other pets to groom or play with the treated pet until the applied sites is completely dry.
  • Keep away from pet’s eyes and mouth.
  • If the solution enters the pet’s eyes accidentally, then flush the eyes with a lot of water.
  • It contains inflammable substance and so needs to be kept away from excessive heat or fire.
  • Keep away from children, food items and animal feeds.
  • Do not drink or smoke while applying the treatment.
  • It proves toxic for human consumption. In case of accidentally swallowing contact Poison Control Center at the earliest.
  • Fipronil
  • (S)-methoprene
Merial / Boehringer Ingelheim