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Just one bite from an infected mosquito is enough to cause the potentially fatal heartworm disease in dogs. The risk is genuine. With all 50 states reporting the cases, the need for effective protection against this deadly disease is more real than ever. So, regardless of where you live in the USA, a heartworm preventive for dogs is unavoidable.
Heartgard Plus is a vet-recommended protection against heartworm disease. Not just a treatment, Heartgard Plus comes in delicious real-beef chew form, making it the #1 dog-preferred chew. With over 30 years of proven protection, this preventive gives you the confidence to prevent heartworm disease. What's more, Heartgard Plus Chew for Dogs also treats and controls 3 species of hookworms and 2 species of roundworms with every single dose, all year long.
Heartgard Plus chewables contain ivermectin and pyrantel as active ingredients. Ivermectin eliminates the tissue stage of heartworm larvae (Dirofilaria immitis). It prevents the development of the adult stage by allowing the immune system of dogs to recognize and inactivate these larvae before they develop into adult worms. Pyrantel targets intestinal worms and treats and controls roundworms and hookworms.
Nuheart - a generic heartgard is an effective heartworm treatment for dogs. Nuheart is a generic version of Heartgard with exactly the same ingredient as in Heartgard. Nuheart is a meat flavored monthly tablet that is easy to dose. It is safe to use for dogs and puppies over 6 weeks of age.
Read More: Difference Between Heartgard Plus VS Generic Nuheart
Manufacturer Merial / Boehringer Ingelheim| Dog Size | Dog Weight | Pack Color | Ivermectin Strength (mcg) | Pyrantel Strength (mg) | Doses Administered |
| Small Dogs | Up to 25.0 lbs | Blue | 68 | 57 | One |
| Medium Dogs | 26 – 50.0 lbs | Green | 136 | 114 | One |
| Large Dogs | 51 – 100.0 lbs | Brown | 272 | 227 | One |
| For dogs over 100.0 lbs, administer the appropriate combination of Heartgard Plus Chews. | |||||
Heartgard Plus is not effective against adult heartworms (Dirofilaria immitis). Test your dogs for existing heartworm infection before starting with heartworm preventive treatment. If your dog is infected, consult a vet to treat the disease and remove heartworms before starting a preventive program.
It is safe at the recommended dose level in pregnant, breeding and stud dogs. Clinical trials suggest that Heartgard Plus can be used with flea collars, shampoos, dips, anthelmintics, antibiotics, vaccines and steroid preparations.
For dogs that swallow treats whole, break the chews into pieces to prevent choking or intestinal obstruction. Keep it out of reach of children, uninformed people and pets.
Do not use Heartgard Plus in puppies under 6 weeks of age.
Store between 68°F - 77°F (20°- 25°C) with excursions permitted between 59°F - 86°F (15°- 30°C). Protect it from light.
Heartgard Plus Ingredients:
Ivermectin, Pyrantel
Nuheart Ingredient:
Ivermectin
Heartgard Plus is a highly palatable, real-beef monthly chew for the prevention of heartworm disease in dogs. It also treats and controls roundworms and hookworms.
Heartworms are transmitted through a bite from an infected mosquito. When a mosquito bites an infected dog, it picks up heartworm larvae (microfilariae), which develop into the infective stage inside the mosquito. This mosquito transmits the infective larvae to a healthy dog by taking a blood meal.
Heartgard Plus is suitable for puppies and dogs from 6 weeks of age. There is no minimum weight requirement for Heartgard Plus.
The threat of heartworm disease does not vanish during cold weather. The risk may be reduced with the dropping temperature, it is never zero. Therefore, it is recommended to administer a heartworm preventive year-round for uninterrupted protection.
Consider your dog's age, breed, drug sensitivity and existing health condition before using Heartgard Plus. Always test your dogs for existing heartworms. Only proceed with the preventive treatment if your dog has a negative heartworm test. Some dog breeds, such as Collies, may have a genetic mutation, making them more sensitive to this treatment. Talk to your vet about your dog's sensitivity. Do not use this treatment if your dog is under 6 weeks of age.
For optimal protection, consult your veterinarian to see whether your pet has ever had an allergic reaction to any of the ingredients in the product, including beef.
If you miss a dose, give a dose as soon as you remember and continue with the monthly schedule.
In case of overdosing, rush to a vet immediately.
Credelio for Dogs is a fast-acting oral chewable treatment for your canine's protection against fleas and ticks. This monthly oral formula starts killing fleas and ticks within just four hours and continues to kill these parasites for the entire month. A single chew protects your dog from five different species of ticks. Due to its ability to kill black-legged vector ticks, Credelio Tick treatment for dogs is recommended for the prevention of Lyme disease (Borrelia burgdorferi) infections.
Credelio is composed with an extra purification step during formulation, leaving only the active portion of the composition in the final treatment. Formulated as a tasty chewable tablet with pork liver and soy flavoring, Credelio makes administration easy and enjoyable for your dog. It is suitable for young puppies and adult dogs. Credelio for fleas comes in five different dosage strengths, catering to dogs of all sizes.
Credelio for Dogs contains lotilaner. After administration, the active ingredient, lotilaner, is absorbed into the dog's bloodstream. When fleas and/or ticks bite a Credelio-treated dog, they ingest lotilaner. This extra-purified formula inhibits the nerve receptors of fleas and ticks, causing uncontrolled activity in their nervous system, leading to death.
According to controlled lab studies referred to in the product label, Credelio began killing fleas four hours after administration or infestation, killing almost all fleas within eight hours. It showed complete efficacy against adult fleas within 12 hours. It also displayed more than 90% efficacy against various tick species 48 hours post-administration or infestation.
Manufacturer Elanco| Dog Weight (lbs) | Pack Color | Lotilaner (mg) | Dose Per Month |
| 4.4 – 6.0 | Yellow | 56.25 | One |
| 6.1 – 12.0 | Pink | 112.50 | One |
| 12.1 – 25.0 | Orange | 225.00 | One |
| 25.1 – 50.0 | Green | 450.00 | One |
| 50.1 – 100.0 | Blue | 900.00 | One |
For dogs over 100.0 lbs, administer the appropriate combination of Credelio chews.
Credelio is not for use in humans. You should keep these chews out of the reach of children, uninformed people and pets. In case of accidental ingestion, immediately consult a physician. The safe use of Credelio has not been evaluated in pregnant, breeding or lactating dogs. You should use these chews with caution in dogs with a history of seizures or neurologic disorders. Do not administer Credelio to puppies under 8 weeks of age or less than 4.4 lbs of body weight.
As per a controlled field study referenced in the label, Credelio was used with other veterinary treatments, such as anthelmintics, vaccines, steroids, antibiotics, anesthetics, antihistamines and NSAIDs without any adverse reactions. You should take out the chew from the blister pack only at the time of dosing.
Lotilaner
Credelio is a tasty, palatable, flavored chewable flea and tick treatment for dogs. It is suitable for use in puppies and dogs from 8 weeks of age and at least 4.4 lbs of body weight.
It is not recommended to take the chews out of the blister pack for storage in another container. The chews should be taken out of the blister pack only at the time of dosing.
Credelio chews feature beef flavoring containing pork liver and soy. They contain no actual beef, but contain barley, wheat and lactose. You should talk to your vet before using it in dogs with food allergies.
Yes. Credelio chews are considered free from gluten.
Credelio is known to kill fleas quickly when administered as per the label. For optimum flea control, you should treat all the animals in the household. Also, your dog can continue to be exposed to new fleas that live in the environment. Once these fleas jump on the dog, Credelio will likely kill them.
Yes. You must administer Credelio with food or within 30 minutes of feeding your dog. This ensures your dog achieves peak blood levels and exposure, which is necessary for initial and ongoing efficacy.
If you miss a dose, immediately give one dose with food and continue with a monthly dosing schedule.
According to controlled lab studies referenced in the label, Credelio (lotilaner) began killing fleas four hours and went on to kill almost all fleas within eight hours after administration or infestation. It demonstrated complete flea efficacy 12 hours after administration or infestation as per another lab study. The formula achieved more than 90% efficacy against different tick species 48 hours post-administration or infestation, as per other studies referenced in the label.
Yes. Credelio works systemically. This means that the parasites (fleas & ticks) must be exposed to the active ingredient, lotilaner, to die.
There are no indications from the manufacturer about splitting Credelio, as they are not scored for splitting. However, a variety of dosage strengths are available to cater to dogs of all sizes.
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