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Heartgard Plus is a beef-flavored chewable to prevent heartworm infection in dogs. It also treats and controls preexisting hookworm and roundworm infections. Heartworms, spread by mosquitoes, can result into fatal diseases when prevented with heartworm preventives. Hence, to protect your pet from deadly diseases, Heartgard is a full proof solution. Heartgard Plus tablets treat small, medium and large sized dogs that falling under three weight ranges – 0-25 lbs, 26-50 lbs and 51-100 lbs respectively. Available in 6-dose and 12-dose packets, these palatable tablets are given as a monthly dosage.
Heartgard Plus contains two potent ingredients - Ivermectin and Pyrantel. The active ingredient Ivermectin eliminates the immature form of heartworms and the other ingredient pyrantel removes hookworms and roundworms. The oral treatment when given monthly protects your dog against dangerous heartworm disease.
It effectively prevents heartworm disease and can be administered monthly starting from 6 weeks old puppies.
Heartgard Plus Chewables for Medium Dogs 26 - 50 lbs (Green) 6 Doses Pack Expiration Date - Aug 2026
Nuheart - a generic heartgard is an effective heartworm treatment for dogs. Nuheart is a generic version of Heartgard with exactly the same ingredient as in Heartgard. Nuheart is a meat flavored monthly tablet that is easy to dose. It is safe to use for dogs and puppies over 6 weeks of age.
Read More: Difference Between Heartgard Plus VS Generic Nuheart
Manufacturer Merial / Boehringer Ingelheim| Pack Size | Strength | Dosage |
| Heartgard Plus Blue (up to 25lbs) |
68mcg Ivermectin, 57mg Pyrantel | One Dose Per Month |
| Heartgard Plus Green (25-60lbs) |
136mcg Ivermectin, 114mg Pyrantel | One Dose Per Month |
| Heartgard Plus Brown (51-100lbs) |
272mcg Ivermectin, 227mg Pyrantel | One Dose Per Month |
Caution:Collies including Border Collies and other breeds are sensitive to Ivermectin. Please consult your vet before giving this treatment or look for alternatives to Ivermectin for the treatment of parasites.
Heartgard Plus Ingredients:
Ivermectin, Pyrantel
Nuheart Ingredient:
Ivermectin
Heartgard Plus chewables are highly-palatable, beef-flavored chews for the prevention of heartworms in dogs and the treatment and control of roundworms and hookworms. Heartgard Plus remains effective for one full month.
Heartworms are transmitted through mosquito bites. When an infected mosquito bites a dog, heartworm larvae get deposited on the skin. These larvae enter the skin through the bite wound and make their way toward the heart.
Heartgard Plus chews contains ivermectin and pyrantel pamoate as its active ingredients. Ivermectin is an antiparasitic that prevents heartworms, whereas, pyrantel is antihelmintic that treats and control roundworms and hookworms.
Heartgard Plus soft chew is a monthly heartworm prevention treatment, so it should be administered regularly every month for continuous protection. It can be given directly to your dog or it may be added to the food after breaking the chew into small pieces.
Heartgard Plus chewable tablets contains Ivermectin and, according to the studies, certain dogs of the Collie breed are more sensitive to its effects when administered at elevated dose levels than other dog breeds. Therefore, it should be used with caution in collies and other herding dog breeds. Moreover, a heartworm test must be performed before starting this prevention treatment and 6 months after using this treatment as already present microfilaria take 6 months to mature.
Ideally, this should not cause any issues. Heartgard Plus is a trusted heartwormer and is safe for dogs. However, it is always safe to consult your veterinarian if your pet has ever had an allergic reaction to any of the ingredients in the product, including beef.
If you miss giving a dose, give it as soon as you remember. Do not double the dose.
Seek veterinary assistance immediately.
Heartgard Plus chews is suitable for use for dogs 6 weeks of age and older. There is no minimum age requirement.
Heartgard Plus is available in 3 dosage strengths:
Credelio for Dogs is a fast-acting oral chewable treatment for your canine's protection against fleas and ticks. This monthly oral formula starts killing fleas and ticks within just four hours and continues to kill these parasites for the entire month. A single chew protects your dog from five different species of ticks. Due to its ability to kill black-legged vector ticks, Credelio Tick treatment for dogs is recommended for the prevention of Lyme disease (Borrelia burgdorferi) infections.
Credelio is composed with an extra purification step during formulation, leaving only the active portion of the composition in the final treatment. Formulated as a tasty chewable tablet with pork liver and soy flavoring, Credelio makes administration easy and enjoyable for your dog. It is suitable for young puppies and adult dogs. Credelio for fleas comes in five different dosage strengths, catering to dogs of all sizes.
Credelio for Dogs contains lotilaner. After administration, the active ingredient, lotilaner, is absorbed into the dog's bloodstream. When fleas and/or ticks bite a Credelio (lotilaner) treated dog, they ingest lotilaner. This extra-purified formula inhibits the nerve receptors of fleas and ticks. It causes uncontrolled activity in the parasites' nervous system, leading to their death.
According to controlled lab studies referred to in the product label, Credelio (lotilaner) began killing fleas four hours after administration or infestation, killing almost all fleas within eight hours after administration or infestation. It showed complete flea efficacy 12 hours after administration or infestation as per another lab study. Credelio (lotilaner) also displayed more than 90% efficacy against various tick species 48 hours post-administration or infestation, based on other studies cited on the label.
| Dog Weight (lbs) | Pack Color | Lotilaner (mg) | Dose Per Month |
| 4.4 – 6.0 | Yellow | 56.25 | One |
| 6.1 – 12.0 | Pink | 112.50 | One |
| 12.1 – 25.0 | Orange | 225.00 | One |
| 25.1 – 50.0 | Green | 450.00 | One |
| 50.1 – 100.0 | Blue | 900.00 | One |
For dogs over 100.0 lbs, administer the appropriate combination of Credelio chews.
Credelio is not for use in humans. You should keep these chews out of the reach of children, uninformed people and pets. In case of accidental ingestion, immediately consult a physician. The safe use of Credelio has not been evaluated in pregnant, breeding or lactating dogs. You should use these chews with caution in dogs with a history of seizures or neurologic disorders. Do not administer Credelio to puppies under 8 weeks of age or less than 4.4 lbs of body weight.
As per a controlled field study referenced in the label, Credelio was used with other veterinary treatments, such as anthelmintics, vaccines, steroids, antibiotics, anesthetics, antihistamines and NSAIDs without any adverse reactions. You should take out the chew from the blister pack only at the time of dosing.
Lotilaner
Credelio is a tasty, palatable, flavored chewable flea and tick treatment for dogs. It is suitable for use in puppies and dogs from 8 weeks of age and at least 4.4 lbs of body weight.
It is not recommended to take the chews out of the blister pack for storage in another container. The chews should be taken out of the blister pack only at the time of dosing.
Credelio chews feature beef flavoring containing pork liver and soy. They contain no actual beef, but contain barley, wheat and lactose. You should talk to your vet before using it in dogs with food allergies.
Yes. Credelio chews are considered free from gluten.
Credelio is known to kill fleas quickly when administered as per the label. For optimum flea control, you should treat all the animals in the household. Also, your dog can continue to be exposed to new fleas that live in the environment. Once these fleas jump on the dog, Credelio will likely kill them.
Yes. You must administer Credelio with food or within 30 minutes of feeding your dog. This ensures your dog achieves peak blood levels and exposure, which is necessary for initial and ongoing efficacy.
If you miss a dose, immediately give one dose with food and continue with a monthly dosing schedule.
According to controlled lab studies referenced in the label, Credelio (lotilaner) began killing fleas four hours and went on to kill almost all fleas within eight hours after administration or infestation. It demonstrated complete flea efficacy 12 hours after administration or infestation as per another lab study. The formula achieved more than 90% efficacy against different tick species 48 hours post-administration or infestation, as per other studies referenced in the label.
Yes. Credelio works systemically. This means that the parasites (fleas & ticks) must be exposed to the active ingredient, lotilaner, to die.
There are no indications from the manufacturer about splitting Credelio, as they are not scored for splitting. However, a variety of dosage strengths are available to cater to dogs of all sizes.
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